In this paper a SystemC-based framework for run-time partial reconfiguration modeling and simulation is introduced which allows to perform early design space exploration for dynamically reconfigurable systems. Besides, a middleware to extend the capability of TLM introducing a semantic to interconnect components described at different abstraction levels or languages is added. This middleware allows to automate the creation of the corresponding communication adapters to these new components. Finally, the services provided by the middleware are described and experimental results are presented to validate the proposal